Defective PITRM 1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration
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چکیده
منابع مشابه
Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration.
Mitochondrial dysfunction and altered proteostasis are central features of neurodegenerative diseases. The pitrilysin metallopeptidase 1 (PITRM1) is a mitochondrial matrix enzyme, which digests oligopeptides, including the mitochondrial targeting sequences that are cleaved from proteins imported across the inner mitochondrial membrane and the mitochondrial fraction of amyloid beta (Aβ). We iden...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2015
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201505894